The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

Prostate Cancer Susceptibility Loci

Added text about a specific haplotype in the Xq27-28 region of HPCX that was found to be significantly associated with X-linked prostate cancer in Finnish families (cited Baffoe-Bonnie et al. and Yaspan et al. as references 54 and 55, respectively).

Added text risk variants on chromosome 8q24 that have been characterized in families with HPC (cited Sun et al. and Beebe-Dimmer et al. as references 87 and 88, respectively).

Added text about a study that was consistent with the hypothesis that BRCA2, but not BRCA1, is a tumor suppressor gene related to prostate cancer risk (cited Willems et al. as reference 114).

Added text about a study that suggests that prostate cancer risk in BRCA1 mutation carriers varies with the location of the mutation, i.e., there is a correlation between genotype and phenotype (cited Cybulski et al. as reference 115).

Added text about the success and limitations of genome-wide association studies (cited Jorgenson et al. as reference 152).

Polymorphisms and Prostate Cancer Susceptibility

Added text about a study that looked at polymorphisms in several genes involved in the biosynthesis, activation, metabolism and degradation of androgens and the stimulation of mitogenic and antiapoptotic activities of normal prostate cells, and their association with prostate cancer (cited Sarma et al. as reference 33).

Psychosocial Issues in Prostate Cancer

Added text about a study of 79 African American men that found that overall knowledge of hereditary prostate cancer was low, especially concepts of genetic susceptibility, indicating a need for increased education.

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